Single-Cell Sequencing of Lung Macrophages and Monocytes Reveals Novel Therapeutic Targets in COPD.

Yushan HuXiaoJian ShaoLi XingXuan LiGeoffrey M NonisGraeme J KoelwynXuekui Zhang Don D Sin

Published in: Cells (2023)

COPD lungs harbor transcriptionally distinct lung macrophages and monocytes, reflective of a dysfunctional and hyperinflammatory state. Inhaled corticosteroids and other compounds can modulate the transcriptomic profile of these cells in patients with COPD.

Keyphrases

single cell
chronic obstructive pulmonary disease
lung function
rna seq
induced apoptosis
cystic fibrosis
dendritic cells
peripheral blood
high throughput
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
signaling pathway
cell proliferation
pi k akt