Selective removal of misfolded SOD1 delays disease onset in a mouse model of amyotrophic lateral sclerosis.
Teng GuanTing ZhouXiaosha ZhangYing GuoChaoxian YangJustin LinJiasi Vicky ZhangYongquan ChengHassan MarzbanYu Tian WangJiming KongPublished in: Cellular and molecular life sciences : CMLS (2023)
The CT4 peptide directs the degradation of misfolded SOD1 in high efficiency and specificity. Selective removal of misfolded SOD1 significantly delays the onset of ALS, demonstrating that misfolded SOD1 is the toxic form of SOD1 that causes motor neuron death. The study proves that selective removal of misfolded SOD1 is a promising treatment for ALS.