Mincle-GSDMD-mediated release of IL-1β small extracellular vesicles from hepatic macrophages in ethanol-induced liver injury.

Quanri ZhangWeiwei LiuKatarzyna BulekHan WangMegan R McMullenXiaoqin WuNicole WelchRenliang ZhangJaividhya DasarathySrinivasan Dasarathy Laura E Nagy Xiaoxia Li

Published in: Hepatology communications (2023)

β-GluCer functions as a danger-associated molecular pattern activating Mincle-dependent gasdermin D-mediated formation and release of IL-1β-containing sEVs, which in turn exacerbate hepatocyte cell death and contribute to the pathogenesis of ALD.

Keyphrases

cell death
signaling pathway
fluorescent probe
single molecule
living cells
cell cycle arrest
pi k akt