Crucial role for sensory nerves and Na/H exchanger inhibition in dapagliflozin and empagliflozin-induced arterial relaxation.

Elizabeth A ForresterMiguel Benítez-AngelesKaitlyn E RedfordTamara RosenbaumGeoffrey W AbbottVincenzo BarreseKim DoraAnthony P AlbertJohs DannesboeIsabelle Salles-CrawleyThomas A JeppsIain A Greenwood

Published in: Cardiovascular research (2024)

SGLT2 inhibitors relax mesenteric arteries by promoting the release of CGRP from sensory nerves in a NHE1-dependent manner.

Keyphrases

high glucose
diabetic rats
drug induced
oxidative stress
endothelial cells
stress induced