Synergistic effect of umbilical cord extracellular vesicles and rhBMP-2 to enhance the regeneration of a metaphyseal femoral defect in osteoporotic rats.

Amelie DelucaAndrea WagnerPatrick HeimelChristian DeiningerFlorian WichlasHeinz RedlEva RohdeHerbert TempferMario GimonaAndreas Traweger

Published in: Stem cell research & therapy (2024)

The present study demonstrates that the co-application of hUC-MSC-sEVs can improve the efficacy of rhBMP-2 to promote the regeneration of osteoporotic bone defects.

Keyphrases

umbilical cord
bone mineral density
mesenchymal stem cells
stem cells
postmenopausal women
recombinant human
wound healing
body composition
soft tissue
bone loss