Arginase Inhibition Suppresses Native Low-Density Lipoprotein-Stimulated Vascular Smooth Muscle Cell Proliferation by NADPH Oxidase Inactivation.

Bon Hyeock Koo Bong Gu YiWi Kwang WangIn Young KoKwang Lae HoeYoung Guen KwonMoo Ho WonYoung Myeong KimHyun Kyo Lim Sungwoo Ryoo

Published in: Yonsei medical journal (2018)

Increased L-arginine levels following limonin-dependent arginase inhibition prohibited NADPH oxidase activation in a PKCβII-dependent manner, and blocked nLDL-stimulated VSMC proliferation.

Keyphrases

smooth muscle
low density lipoprotein
cell proliferation
signaling pathway
nitric oxide
nitric oxide synthase
cell cycle
amino acid