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Surgical suction filter-derived bone graft displays osteogenic miRNA and mRNA patterns.

Rald V M GrovenJob T BlokhuisMartijn PoezeMartijn van GriensvenTaco J Blokhuis
Published in: European journal of trauma and emergency surgery : official publication of the European Trauma Society (2023)
This study revealed distinctly deregulated and exclusively expressed osteogenic miRNAs in SF-BGS, as well as overall enhanced osteogenic marker gene expression, as compared to the venous blood control group. These expression profiles were not seen in control samples, indicating that the derived material displays an osteogenic profile. It may therefore be a promising tool to generate a BGS or graft extender when needed.
Keyphrases
  • mesenchymal stem cells
  • bone marrow
  • gene expression
  • dna methylation
  • bone mineral density
  • soft tissue