Irbesartan decreased mitochondrial stress related apoptosis in cisplatin induced acute kidney injury via regulating BCL-2/BAX signaling.

İlter İlhan Halil Aşçi Nursel Hasseyid Hatice Kubra Doğan Serife Tasan Melike Altintaş Muhammet Yusuf Tepebasi

Published in: Molecular biology reports (2022)

IBN significantly regressed kidney damage by its anti-inflammatory and antioxidant activity via inhibiting mitochondrial stress. IBN could be used as a renoprotective agent in CPN-induced kidney injury.

Keyphrases

oxidative stress
diabetic rats
acute kidney injury
anti inflammatory
induced apoptosis
stress induced
high glucose
endoplasmic reticulum stress
signaling pathway
cell death
cell cycle arrest
heat stress