Challenges of estimating treatment effects after a positive interim analysis.
Yu Yang SoonIan C MarschnerManjula SchouChristopher J SweeneyIan D DavisMartin R StocklerAndrew J Martin
Published in: European journal of cancer (Oxford, England : 1990) (2024)
Overestimation bias, non-proportional hazards, and heterogeneity in recruitment and other important treatments should be considered when communicating estimates of treatment effects from positive IAs.