Inhibition of Ferroptosis by Mesenchymal Stem Cell-Derived Exosomes in Acute Spinal Cord Injury: Role of Nrf2/GCH1/BH4 Axis.

Yixin ChenBingfa LiJing QuanZhe LiYan LiYinbo Tang

Published in: Neurospine (2024)

In summary, the study demonstrates that MSC-Exo mitigates microglial cell ferroptosis via the Nrf2/GCH1/BH4 axis, showing potential for preserving and restoring neurological function post-SCI.

Keyphrases

spinal cord injury
cell death
oxidative stress
stem cells
neuropathic pain
liver failure
spinal cord
mesenchymal stem cells
bone marrow
single cell
cell therapy
drug induced
respiratory failure
aortic dissection
human health
climate change