The TLR1 gene is associated with higher protection from leprosy in women.
Eyleen Nabyla Alvarenga NiitsumaGabriel da Rocha FernandesFrancisco Carlos Félix LanaPublished in: PloS one (2018)
Leprosy is an infectious disease with a complex genetic and immunological background. Polymorphisms in genes that encode cytokines and receptors involved in the immune response, such as the Toll-like receptor 1 (TLR1), may be associated with disease risk. We hypothesized that polymorphisms in innate immunity genes confer susceptibility to leprosy that differs between women and men. In this study, we investigate sex differences in the association between a single nucleotide polymorphism (SNP) in TLR1 and Nucleotide-binding oligomerization domain containing 2 (NOD2) genes and leprosy susceptibility in 256 clinically classified leprosy patients and 233 control subjects in a Brazilian population. Our results showed no association between the SNP rs8057341 in NOD2 and leprosy in this population. However, the heterozygous genotype of the TLR1 SNP (rs4833095) showed a statistically significant association in women (OR = 0.54, P = 0.02). Our findings suggest that the TLR1 polymorphism was associated with an increased protection from leprosy in women.
Keyphrases
- toll like receptor
- genome wide
- immune response
- inflammatory response
- polycystic ovary syndrome
- nuclear factor
- dna methylation
- pregnancy outcomes
- genome wide identification
- end stage renal disease
- copy number
- cervical cancer screening
- ejection fraction
- chronic kidney disease
- breast cancer risk
- newly diagnosed
- type diabetes
- patient reported outcomes
- transcription factor
- early onset
- high density
- gene expression