ASCL1-regulated DARPP-32 and t-DARPP stimulate small cell lung cancer growth and neuroendocrine tumour cell proliferation.

Sk Kayum AlamLi WangYanan RenChristina E HernandezFarhad KosariAnja C RodenRendong YangLuke H Hoeppner

Published in: British journal of cancer (2020)

We reveal new regulatory mechanisms of SCLC oncogenesis that suggest DARPP-32 isoforms may represent a negative prognostic indicator for SCLC and serve as a potential target for the development of new therapies.

Keyphrases

small cell lung cancer
cell proliferation
transcription factor
cell cycle
brain metastases
human health
risk assessment
pi k akt