Synthesis of trifluoromethyl N , N -aminals from nitrogen containing heterocycles by using a plasma flow microreactor.

Trifluoromethyl N , N -aminals are important precursors allowing access to fluorinated building blocks. In this work, the direct synthesis of trifluoromethyl N , N -aminals from nitrogen containing heterocycles is reported using argon plasma in a continuous flow microreactor without any additives or metal catalysts. Their transformation to N -trifluoroethyl amines is also reported.