Gastric adenocarcinoma (GAS) is a rare subtype of mucinous adenocarcinoma characterized by gastric differentiation and is unrelated to human papillomavirus (HPV) infection. This report discusses a 40-year-old female who presented with abdominal distension accompanied by increased abdominal circumference. CT of the abdomen and pelvis showed a large 21.0*12.7*26.0 cm mass later diagnosed as GAS combined with squamous cell carcinoma on surgical pathology. Immunohistological staining of GAS was positive for CK7, MUC6, PAX-8 CEA, and P53 (wild type) and negative for CDX2, CK20, ER, PR, P16, and WT1. The proliferative index (Ki-67) was 20%. Immunohistochemical staining of squamous cell carcinoma was positive for P16 and P53 (wild type), and the proliferative index (Ki-67) was 90%. However, the pathogenesis and molecular mechanisms of GAS have not been fully elucidated. As more cases are identified and reported, additional targeted therapies can be developed and tested in these patients.
Keyphrases
- squamous cell carcinoma
- wild type
- locally advanced
- room temperature
- end stage renal disease
- neoadjuvant chemotherapy
- lymph node metastasis
- carbon dioxide
- body mass index
- newly diagnosed
- peritoneal dialysis
- chronic kidney disease
- computed tomography
- protein kinase
- prognostic factors
- magnetic resonance imaging
- radiation therapy
- rectal cancer
- low grade
- contrast enhanced
- physical activity
- dual energy
- magnetic resonance
- preterm birth
- patient reported outcomes
- body weight
- lymph node
- cord blood
- estrogen receptor