Genipin and insulin combined treatment improves implant osseointegration in type 2 diabetic rats.

Jiajia ZhangYa-Nan WangTingting JiaHaiyun HuangDongjiao ZhangXin Xu

Published in: Journal of orthopaedic surgery and research (2021)

Our study suggests that treatment with genipin in combination with insulin could be an effective method for promoting implant osseointegration in T2DM rats, which may be related to AMPK signaling.

Keyphrases

type diabetes
diabetic rats
oxidative stress
glycemic control
skeletal muscle
metabolic syndrome
combination therapy
replacement therapy
smoking cessation