Histone deacetylase activity is a novel target for epithelial barrier defects in patients with eosinophilic chronic rhinosinusitis with nasal polyps.

Su DuanXinling HanJian JiaoMing WangYing LiYang WangLuo Zhang

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2022)

Our data suggest that eosinophilia and HDACs influence epithelial barrier function in CRSwNP patients by regulating TJ protein expression. Targeting HDACs with specific inhibitors may be a potential treatment option for patients with eosinophilic CRSwNP.

Keyphrases

chronic rhinosinusitis
histone deacetylase
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
cancer therapy
risk assessment
patient reported outcomes
machine learning
big data
deep learning