Bone morphogenetic protein 9 as a key regulator of liver progenitor cells in DDC-induced cholestatic liver injury.

Annalisa AddanteCesáreo RonceroLaura AlmaléNerea LazcanoiturburuMaría García-ÁlvaroMargarita FernándezJulián SanzSeddik HammadZeribe C NwosuSe-Jin LeeIsabel FabregatSteven DooleyPeter Ten DijkeBlanca HerreraAránzazu Sánchez

Published in: Liver international : official journal of the International Association for the Study of the Liver (2018)

We identify BMP9 as a negative regulator of oval cell expansion in cholestatic injury, its deletion enhancing liver regeneration. Likewise, our work further supports BMP9 as an attractive therapeutic target for chronic liver diseases.

Keyphrases

liver injury
drug induced
mesenchymal stem cells
stem cells
transcription factor
cell therapy
bone marrow
wound healing