Comparative genomic analyses highlight the contribution of pseudogenized protein-coding genes to human lincRNAs.
Wan-Hsin LiuZing Tsung-Yeh TsaiHuai-Kuang TsaiPublished in: BMC genomics (2017)
We suggest that a notable portion of lincRNAs could be derived from pseudogenized protein-coding genes. Furthermore, based on our computational analysis, we hypothesize that a subset of these lincRNAs could have potential to regulate their paralogs by functioning as competing endogenous RNAs. Our results provide evolutionary evidence of the relationship between human lincRNAs and protein-coding genes.