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Comparative genomic analyses highlight the contribution of pseudogenized protein-coding genes to human lincRNAs.

Wan-Hsin LiuZing Tsung-Yeh TsaiHuai-Kuang Tsai
Published in: BMC genomics (2017)
We suggest that a notable portion of lincRNAs could be derived from pseudogenized protein-coding genes. Furthermore, based on our computational analysis, we hypothesize that a subset of these lincRNAs could have potential to regulate their paralogs by functioning as competing endogenous RNAs. Our results provide evolutionary evidence of the relationship between human lincRNAs and protein-coding genes.
Keyphrases
  • genome wide
  • endothelial cells
  • protein protein
  • amino acid
  • genome wide identification
  • binding protein
  • dna methylation
  • small molecule
  • risk assessment
  • human health
  • data analysis