Protein phosphatase 2A modulates podocyte maturation and glomerular functional integrity in mice.

Xiujuan ZhuYuhong YeChengxian XuCunji GaoYingying ZhangJing ZhouWeiqiang LinJian-Hua Mao

Published in: Cell communication and signaling : CCS (2019)

Our study revealed the important role of PP2A in regulating the development of foot processes and fully differentiated podocytes whereas fine-tuning of YB-1 via a post-translational modification by PP2A regulating its activity might be crucial for the functional integrity of podocytes and glomerular filtration barrier.

Keyphrases

diabetic nephropathy
high glucose
endothelial cells
single cell
protein protein
metabolic syndrome
type diabetes
amino acid
adipose tissue