Protein phosphatase 2A modulates podocyte maturation and glomerular functional integrity in mice.
Xiujuan ZhuYuhong YeChengxian XuCunji GaoYingying ZhangJing ZhouWeiqiang LinJian-Hua MaoPublished in: Cell communication and signaling : CCS (2019)
Our study revealed the important role of PP2A in regulating the development of foot processes and fully differentiated podocytes whereas fine-tuning of YB-1 via a post-translational modification by PP2A regulating its activity might be crucial for the functional integrity of podocytes and glomerular filtration barrier.