An integrated computational-experimental approach reveals Yersinia pestis genes essential across a narrow or a broad range of environmental conditions.
Nicola J SeniorKalesh SasidharanRichard J SaintAndrew E ScottMitali Sarkar-TysonPhilip M IrelandHelen L BullifentZ Rong YangKaren MoorePetra C F OystonTimothy P AtkinsHelen S AtkinsOrkun S SoyerRichard W TitballPublished in: BMC microbiology (2017)
Using an integrated computational-experimental approach we identify genes which are required for growth at 37 °C and under a broad range of environments may be the best targets for the development of new interventions to prevent or treat plague in humans.