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Hypoxic microenvironment-induced exosomes confer temozolomide resistance in glioma through transfer of pyruvate kinase M2.

Guofu LiZiyu XiongYing LiCong YanYingying ChengYuwen WangJingwei LiZifeng DaiDongdong ZhangWenzhong DuChunyang MenChangbin Shi
Published in: Discover oncology (2024)
In the hypoxic microenvironment, glioma cells become resistant to TMZ due to the delivery of PKM2 by exosomes. Targeted modulation of exosomal PKM2 may be a promising strategy for overcoming TMZ resistance in glioma.
Keyphrases
  • stem cells
  • mesenchymal stem cells
  • high glucose
  • diabetic rats
  • cancer therapy
  • tyrosine kinase
  • drug induced
  • newly diagnosed
  • endothelial cells