Postpubertal spermatogonial stem cell transplantation restores functional sperm production in rhesus monkeys irradiated before and after puberty.

Gunapala ShettyJennifer M MitchellTruong N A LamThien T PhanJie ZhangRamesh C TailorKaren A PetersMaria Cecilia PenedoCarol B HannaAmander T ClarkKyle E OrwigMarvin L Meistrich

Published in: Andrology (2021)

The results further support that sperm production can be restored in non-human primates from tissues cryopreserved prior to prepubertal and post-pubertal gonadotoxic treatment by transplantation of these testicular cells after puberty into seminiferous tubules.

Keyphrases

stem cell transplantation
high dose
induced apoptosis
endothelial cells
gene expression
induced pluripotent stem cells
low dose
stem cells
signaling pathway
bone marrow
mesenchymal stem cells
oxidative stress
cell therapy
umbilical cord
cord blood