Survival and Intra-Nuclear Trafficking of Burkholderia pseudomallei: Strategies of Evasion from Immune Surveillance?

Jamuna VadiveluKumutha Malar VellasamyJaikumar ThimmaVanitha MariappanWen-Tyng KangLeang-Chung ChohEsaki Muthu ShankarKum Thong Wong

Published in: PLoS neglected tropical diseases (2017)

B. pseudomallei was found within the nuclear compartment of host cells. The nucleus may play a role as an occult or transient niche for persistence of intracellular pathogens, potentially leading to recurrrent episodes or recrudescence of infection.

Keyphrases

induced apoptosis
cell cycle arrest
public health
gram negative
cerebral ischemia
cell death
signaling pathway
oxidative stress
brain injury
subarachnoid hemorrhage
blood brain barrier