Impact of the body mass index on perioperative immunological disturbances in patients with hip and knee arthroplasty.
Simon Jasinski-BergnerAnna-Luise RadetzkiJanine JahnDavid WohlrabHeike KielsteinPublished in: Journal of orthopaedic surgery and research (2017)
The known wound-healing problems in obese patients and the osteoarthritis per se can be linked to the BMI. While obese patients exerted reduced peripheral NK cells and cytotoxic T cells (CTLs), IL-6 showed no involvement. However, the adipokine leptin strongly increased with the BMI strengthening its role as immunomodulatory molecule negatively interfering the functions of immune effector cells.
Keyphrases
- obese patients
- body mass index
- bariatric surgery
- nk cells
- gastric bypass
- roux en y gastric bypass
- weight gain
- wound healing
- induced apoptosis
- mental health
- cell cycle arrest
- weight loss
- physical activity
- cardiac surgery
- rheumatoid arthritis
- patients undergoing
- dendritic cells
- regulatory t cells
- knee osteoarthritis
- signaling pathway
- immune response
- oxidative stress
- type iii