Differential serum levels of CACNA1C, circadian rhythm and stress response molecules in subjects with bipolar disorder: Associations with genetic and clinical factors.

Obie AllenBrandon J CoombesVanessa PazdernikBarbara GisabellaJoshua HartleyJoanna M BiernackaMark A FryeMatej MarkotaHarry Pantazopoulos

Published in: Journal of affective disorders (2024)

Our findings represent the first evidence for increased serum levels of CACNA1C in BD. Along with altered levels of SST, ARNTL, and CRH our findings suggest CACNA1C is associated with circadian rhythm and stress response disturbances in BD.

Keyphrases

bipolar disorder
atrial fibrillation
heart rate
major depressive disorder
gene expression
copy number