Testis-Specific Protein, Y-Encoded-Like 2 Activates JAK2/STAT3 Pathway in Hypothalamic Paraventricular Nucleus to Sustain Hypertension.

Ying LiYang-Fei XuHong-Li ChiJia-Yue YuYa-Nan GaoHong-Bao LiYu-Ming KangXiao-Jing Yu

Published in: American journal of hypertension (2024)

JAK2/STAT3 is regulated by TSPYL2 in the PVN of SHRs, and PVN TSPYL2/JAK2/STAT3 is essential for maintaining high BP in hypertensive rats, making it a potential therapeutic target for hypertension.

Keyphrases

blood pressure
protein protein
amino acid
binding protein
small molecule