Thermogenic activation represses autophagy in brown adipose tissue.

M CairóJ VillarroyaR CereijoL CampderrósMarta GiraltF Villarroya

Published in: International journal of obesity (2005) (2016)

Our results show a noradrenergic-mediated inverse relationship between autophagy and thermogenic activity in BAT and point toward autophagy repression as a component of brown adipocyte adaptive mechanisms to activate thermogenesis.

Keyphrases

adipose tissue
cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
insulin resistance
high fat diet
type diabetes