Regional Brain Growth Trajectories in Fetuses with Congenital Heart Disease.

Caitlin K RollinsCynthia M OrtinauChristian StoppKevin G FriedmanWayne TworetzkyBorjan GagoskiClemente Velasco-AnnisOnur AfacanLana VasungJeanette I BeauteValerie RofebergJudy A EstroffP Ellen GrantJanet S SoulEdward YangDavid WypijAli GholipourSimon K WarfieldJane W Newburger

Published in: Annals of neurology (2020)

Fetuses with CHD, especially those with lowest cerebral substrate delivery, show a region-specific pattern of small brain volumes and impaired brain growth before 32 weeks gestation. The brains of fetuses with CHD were more similar to those of CHD-related than optimal controls, suggesting genetic or environmental factors also contribute. ANN NEUROL 2021;89:143-157.

Keyphrases

gestational age
resting state
white matter
cerebral ischemia
functional connectivity
preterm birth
depressive symptoms
genome wide
subarachnoid hemorrhage
preterm infants
multiple sclerosis
gene expression
dna methylation
copy number
drug induced
neural network