Epigenetic control of adamantinomatous craniopharyngiomas.
Junier Marrero GutierrezAna Carolina BuenoClarissa Silva MartinsFernanda Borchers Coeli-LacchiniRui M Patrício Silva-JúniorGabriel Henrique Marques GonçalvesJorge Guilherme Okanobo OzakiDanillo C de Almeida E SilvaLuiz Eduardo WildembergXimene Lima da Silva AntunesAntônio Carlos Dos SantosHélio Rubens MachadoMarcelo Volpon SantosAyrton Custodio MoreiraMônica Roberto GadelhaRicardo Zorzetto Nicoliello VêncioSonir Roberto Rauber AntoniniMargaret de CastroPublished in: The Journal of clinical endocrinology and metabolism (2024)
Two clusters of ACP patients were consistently revealed by unsupervised machine learning methods, being one of them significantly hypomethylated, enriched by CTNNB1 mutated ACPs, and associated with increased tumor size. Enrichment analysis reinforced pathways involved in tumor proliferation and in cell-specific tumoral microenvironment.