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The first Japanese biobank of patient-derived pediatric acute lymphoblastic leukemia xenograft models.

Kuniaki TanakaItaru KatoYuu DobashiJun-Ichi ImaiTakashi MikamiHirohito KubotaHiroo UenoMamoru ItoSeishi OgawaTatsutoshi NakahataJunko TakitaHidemi ToyodaChitose OgawaSouichi AdachiShinya WatanabeHiroaki Goto
Published in: Cancer science (2022)
A lack of practical resources in Japan has limited preclinical discovery and testing of therapies for pediatric relapsed and refractory acute lymphoblastic leukemia (ALL), which has poor outcomes. Here, we established 57 patient-derived xenografts (PDXs) in NOD.Cg-Prkdc scid ll2rg tm1Sug /ShiJic (NOG) mice and created a biobank by preserving PDX cells including three extramedullary relapsed ALL PDXs. We demonstrated that our PDX mice and PDX cells mimicked the biological features of relapsed ALL and that PDX models reproduced treatment-mediated clonal selection. Our PDX biobank is a useful scientific resource for capturing drug sensitivity features of pediatric patients with ALL, providing an essential tool for the development of targeted therapies.
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