Zinc Sulfate in Narrow Range as an In Vitro Anti-HSV-1 Assay.

Mona FaniNastaran KhodadadSaeedeh EbrahimiRahil NahidsamieiManoocher MakvandiAli TeimooriHadis Langari

Published in: Biological trace element research (2019)

This report explains the employing of a combination test of traditional cell culture with a quantitative real-time PCR for assessment of the antiviral effect of zinc sulfate (ZnSO4) on herpes simplex virus (HSV)-infected Vero cells. Our evidence showed that the treatment with 0.3 mM ZnSO4 strongly inhibited the replication of virus progeny (MOI 0.001) at least 68-fold less. On the other hand, the IC50 demonstrated that the highest activity of ZnSO4 was at the 0.23 mM concentration.

Keyphrases

herpes simplex virus
real time pcr
induced apoptosis
oxide nanoparticles
cell cycle arrest
high throughput
high resolution
oxidative stress
signaling pathway
cell death
combination therapy
single cell
replacement therapy