Microglia lacking a peroxisomal β-oxidation enzyme chronically alter their inflammatory profile without evoking neuronal and behavioral deficits.
Lien BeckersIvana GericStijn StroobantsSander BeelPhilip Van DammeRudi D'HoogeMyriam BaesPublished in: Journal of neuroinflammation (2019)
Our data demonstrate that MFP2 deficiency in microglia causes intrinsic dysregulation of their inflammatory profile, which is not harmful to neuronal function, motor function, and cognition in mice during their first year of life.
Keyphrases
- inflammatory response
- oxidative stress
- neuropathic pain
- traumatic brain injury
- cerebral ischemia
- electronic health record
- mild cognitive impairment
- hydrogen peroxide
- big data
- type diabetes
- multiple sclerosis
- spinal cord injury
- adipose tissue
- blood brain barrier
- insulin resistance
- subarachnoid hemorrhage
- electron transfer