Type I interferon responses are impaired in latently HIV infected cells.

Nischal RanganathTeslin S SandstromSaleh FadelSandra C CôtéJonathan B Angel

Published in: Retrovirology (2016)

In comparison to the HIV-uninfected U937 and HL60 cell lines, widespread defects in IFN-I responsiveness were observed within the latently HIV-infected U1 and OM10.1 cells. These impairments represent novel therapeutic targets, which may be amenable to strategies currently employed in cancer therapy.

Keyphrases

hiv infected
antiretroviral therapy
induced apoptosis
human immunodeficiency virus
cancer therapy
cell cycle arrest
hiv positive
hiv aids
signaling pathway
immune response
endoplasmic reticulum stress
cell death
cell proliferation
pi k akt