Engineering small-molecule analogues of altiratinib via CREB-regulated transcription co-activator 3-target screening for the development of potent and safe topical therapeutics against skin hyperpigmentary diseases.

Jeong Hyeon LeeHongchan AnHyeJi KwonSu-Jeong LeeYoung Hye ParkJi Sun HwangMin Young KimHayoung HwangJeong Yoon KimSeung Jin LeeSung Eun ChangYoungsup Song

Published in: Clinical and translational medicine (2024)

Keyphrases

small molecule
wound healing
transcription factor
protein protein
nuclear factor
soft tissue
molecular docking
anti inflammatory
immune response
structure activity relationship
molecular dynamics simulations