Autophagy Inhibition-induced Cytosolic DNA Sensing Combined with Differentiation Therapy Induces Irreversible Myeloid Differentiation in Leukemia Cells.
Tomohisa BabaUtano TomaruAtsushi HiraoNaofumi MukaidaYoshikazu JohmuraPublished in: Cancer research communications (2024)
Clinical effects on AML therapy are closely associated with reactivating the normal myeloid differentiation potential in leukemia cells. This study shows that autophagosome formation inhibitors activate the cytosolic DNA-sensor signaling, thereby augmenting conventional differentiation therapy to induce irreversible differentiation and cell growth arrest in several types of AML cell lines.
Keyphrases
- acute myeloid leukemia
- induced apoptosis
- bone marrow
- cell cycle arrest
- dendritic cells
- cell death
- endoplasmic reticulum stress
- single molecule
- oxidative stress
- signaling pathway
- stem cells
- allogeneic hematopoietic stem cell transplantation
- mesenchymal stem cells
- cell proliferation
- diabetic rats
- drug induced
- high glucose
- acute lymphoblastic leukemia
- endothelial cells
- cell therapy
- stress induced
- smoking cessation