The proliferation/migration ability mediated by CD151/PI3K/AKT pathway determines the therapeutic effect of hUC-MSCs transplantation on rheumatoid arthritis.

Xuewei XiaPeixin ShenGuomei YangMengwei YaoXiaofeng WuLina LyuYanji HeZhuxin LiWei WangYi YangXiang AoChuanjiang XiaZhuo ChenXiang Xu

Published in: Clinical and experimental hypertension (New York, N.Y. : 1993) (2024)

IFN-γ facilitates the proliferation and migration of hUC-MSCs through the CD151/PI3K/AKT pathway. The therapeutic efficacy of siRNA-CD151-hUC-MSCs was found to be inferior to that of siRNA-NC-hUC-MSCs.

Keyphrases

mesenchymal stem cells
umbilical cord
rheumatoid arthritis
nk cells
immune response
signaling pathway
disease activity
cell therapy
bone marrow
systemic lupus erythematosus
ankylosing spondylitis