Targeting glioblastoma tumor hyaluronan to enhance therapeutic interventions that regulate metabolic cell properties.
Edward R NevesAchal AnandJoseph MuellerRoddel A RemyHui XuKim A SeltingJann N SarkariaBrendan A C HarleySara Pedron-HabaPublished in: bioRxiv : the preprint server for biology (2024)
The control of aberrant hyaluronan metabolism in the tumor microenvironment can improve the efficacy of current treatments. Bioengineered preclinical models demonstrate potential to predict, stratify and accelerate the development of cancer treatments.