A newly-synthesized compound CP-07 alleviates microglia-mediated neuroinflammation and ischemic brain injury via inhibiting STAT3 phosphorylation.
Mengdi GuoQian CaoShengnan XiaXiang CaoJian ChenYi QianXinyu BaoYun XuPublished in: Journal of translational internal medicine (2023)
We showed that a newly synthesized compound, CP-07, could effectively reduce the inflammatory responses in LPS-stimulated BV2 cells and primary mouse microglia, and overproduction of cytokines in middle cerebral artery occlusion mouse models by inhibiting STAT3 phosphorylation, leading to a neuroprotective effect on I/R brain injury.
Keyphrases
- brain injury
- cerebral ischemia
- middle cerebral artery
- inflammatory response
- subarachnoid hemorrhage
- lipopolysaccharide induced
- lps induced
- induced apoptosis
- signaling pathway
- mouse model
- internal carotid artery
- cell proliferation
- protein kinase
- cell cycle arrest
- neuropathic pain
- traumatic brain injury
- cell death
- pi k akt
- spinal cord
- oxide nanoparticles
- oxidative stress
- blood brain barrier