Metabolomic phenotyping of obesity for profiling cardiovascular and ocular diseases.
Pingting ZhongShaoying TanZhuoting ZhuGabriella BullochErping LongWenyong HuangMingguang HeMingguang HePublished in: Journal of translational medicine (2023)
Gaps of metBMI and actBMI identified novel metabolic subtypes, which exhibit distinctive cardiovascular and ocular risk profiles. The groups carrying obesity-related metabolites were at higher risk of mortality and morbidity than those with normal health metabolites. Metabolomics allowed for leveraging the future of diagnosis and management of 'healthily obese' and 'unhealthily lean' individuals.
Keyphrases
- weight loss
- metabolic syndrome
- insulin resistance
- type diabetes
- ms ms
- high fat diet induced
- weight gain
- bariatric surgery
- public health
- healthcare
- adipose tissue
- cardiovascular events
- mental health
- single cell
- high throughput
- risk factors
- optic nerve
- mass spectrometry
- body mass index
- coronary artery disease
- current status
- physical activity
- risk assessment
- human health
- health promotion
- social media
- optical coherence tomography