Exome-chip association analysis of intracranial aneurysms.

Femke N G van 't HofDongbing LaiJessica van SettenMichiel L BotsIlonca VaartjesJoseph BroderickDaniel WooTatiana ForoudGabriel J E RinkelPaul I W de BakkerYnte M Ruigrok

Published in: Neurology (2019)

Gene-based tests indicated an association for FBLN2, a gene encoding an extracellular matrix protein implicated in vascular wall remodeling, but independent validation in larger cohorts is warranted. We did not identify any significant associations for single low-frequency genetic variants.

Keyphrases

extracellular matrix
copy number
genome wide
genome wide identification
high throughput
gene expression
amino acid
transcription factor
protein protein