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Stevioside Ameliorates Palmitic Acid-Induced Abnormal Glucose Uptake via the PDK4/AMPK/TBC1D1 Pathway in C2C12 Myotubes.

Changfa ZhangShuai LiLikang LiRuoting WangShiming LuoGuowei Li
Published in: Endocrinology, diabetes & metabolism (2024)
SV was found to ameliorate PA-induced abnormal glucose uptake via the PDK4/AMPK/TBC1D1 pathway in C2C12 myotubes. Although these results warranted further investigation for validation, they may provide some evidence of SV as a safe natural sweetener for its use in sugar-free beverages to prevent and control T2DM.
Keyphrases
  • skeletal muscle
  • blood glucose
  • high glucose
  • diabetic rats
  • protein kinase
  • mouse model
  • type diabetes
  • oxidative stress
  • endothelial cells
  • blood pressure
  • stress induced