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Trial of magnetic resonance-guided putaminal gene therapy for advanced Parkinson's disease.

John D HeissCodrin LunguDima A HammoudPeter HerscovitchDebra J EhrlichDavis P ArgersingerSanhita SinharayGretchen ScottTianxia WuHoward J FederoffKareem A ZaghloulMark HallettRussell R LonserKrystof S Bankiewicz
Published in: Movement disorders : official journal of the Movement Disorder Society (2019)
Adeno-associated virus, serotype-2 vector carrying glial cell line-derived neurotrophic factor infusion was safe and well tolerated. Increased [18 F]FDOPA uptake suggests a neurotrophic effect on dopaminergic neurons. © 2019 International Parkinson and Movement Disorder Society.
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