Role of Cyclosporine in Gingival Hyperplasia: An In Vitro Study on Gingival Fibroblasts.

Lauritano DorinaAnnalisa PalmieriAlberta LuccheseDario Di StasioGiulia MoreoFrancesco Carinci

Published in: International journal of molecular sciences (2020)

Data collected demonstrate that cyclosporine inhibits the secretion of matrix proteases, contributing to the accumulation of extracellular matrix components in the gingival connective tissue, causing gingival overgrowth. Patients affected by gingival overgrowth caused by cyclosporine A need to be further investigated in order to determine the role of this drug on fibroblasts.

Keyphrases

extracellular matrix
end stage renal disease
newly diagnosed
ejection fraction
peritoneal dialysis
emergency department
electronic health record
machine learning
patient reported outcomes
high resolution
patient reported