Imipenem plus Fosfomycin as Salvage Therapy for Vertebral Osteomyelitis.

Itaru NakamuraTetsuo Yamaguchi Kotaro AokiYuri MiuraSatoko SatoHiroaki FujitaHidehiro Watanabe

Published in: Antimicrobial agents and chemotherapy (2020)

We applied combination antibiotic therapy to treat vertebral osteomyelitis and a psoas abscess caused by glycopeptide-intermediate (MIC, 2 μg/ml) and daptomycin-nonsusceptible (>2 μg/ml) methicillin-resistant Staphylococcus aureus The Etest synergy test showed the largest synergistic effects for imipenem/cilastatin and fosfomycin. Whole-gene sequencing showed amino acid changes in SA0802, SA1193 (mprF), and SA1531 (ald). Four weeks of combination treatment using imipenem/cilastatin (1.5 g per day) and fosfomycin (4.0 g per day) resulted in clinical improvement.

Keyphrases

methicillin resistant staphylococcus aureus
urinary tract infection
staphylococcus aureus
amino acid
gram negative
bone mineral density
copy number
genome wide
single cell
multidrug resistant
cancer therapy
stem cells
postmenopausal women
replacement therapy
mesenchymal stem cells
cell therapy
bone marrow