Xylazine effects on opioid-induced brain hypoxia.

Shinbe ChoiMatthew R IrwinEugene A Kiyatkin

Published in: Psychopharmacology (2023)

These findings suggest that xylazine exacerbates the life-threatening effects of opioids, proposing worsened brain hypoxia as the mechanism contributing to xylazine-positive opioid-overdose deaths.

Keyphrases

chronic pain
pain management
resting state
white matter
endothelial cells
high glucose
functional connectivity
cerebral ischemia
diabetic rats
multiple sclerosis