Aldehyde dehydrogenase 2-mediated aldehyde metabolism promotes tumor immune evasion by regulating the NOD/VISTA axis.

Yuru ChenJiazheng SunJiazhou LiuYuxian WeiXiaoyu WangHuiying FangHuimin DuJing HuangQin LiGuosheng RenXiaoyi WangHongzhong Li

Published in: Journal for immunotherapy of cancer (2023)

Our data delineate that ALDH2-mediated aldehyde metabolism drives tumor immune evasion by activating the NOD/NF-κB/VISTA axis. Targeting ALDH2 provides an effective combinatorial therapeutic strategy for immunotherapy.

Keyphrases

signaling pathway
electronic health record
big data
cancer therapy
innate immune
immune response
nuclear factor
artificial intelligence
toll like receptor