Synchronous Detection of Circulating Tumor Cells in Blood and Disseminated Tumor Cells in Bone Marrow Predicts Adverse Outcome in Early Breast Cancer.

Mark Jesus M MagbanuaChristina YauDenise M WolfJin Sun LeeAheli ChattopadhyayJanet H ScottErin Bowlby-YoderE Shelley HwangMichael AlvaradoCheryl A EwingAmy L DelsonLaura van 't VeerLaura EssermanJohn W Park

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Detection of CTCs in patients with HR-positive early breast cancer was an independent prognostic factor for DRFS (using CellSearch) and BCSS (using IE/FC). Simultaneous detection of DTCs provided additional prognostic power for outcome, including OS.

Keyphrases

early breast cancer
circulating tumor cells
prognostic factors
bone marrow
loop mediated isothermal amplification
real time pcr
label free
circulating tumor
sensitive detection