Hypoxia-driven immunosuppression by Treg and type-2 conventional dendritic cells in HCC.

Sheena SuthenChun Jye LimPhuong H D NguyenCharles-Antoine DutertreHannah L H LaiMartin WasserCamillus ChuaTony K H LimWei Qiang LeowTracy Jiezhen LohWei Keat WanYin Huei PangGwyneth SoonPeng Chung CheowJuinn Huar KamShridhar IyerAlfred KowWai Leong TamTimothy W H ShuenHan Chong TohYock Young DanGlenn K BonneyChung Yip ChanAlexander ChungBrian K P GohWeiwei ZhaiFlorent GinhouxPierce K H ChowSalvatore AlbaniValerie Chew

Published in: Hepatology (Baltimore, Md.) (2022)

We uncovered the unique immunosuppressive landscapes and identified key immune subsets enriched in hypoxic HCC. In particular, we identified a potential Treg-mediated immunosuppression through interaction with a cDC2 subset in HCC that could be exploited for immunotherapies.

Keyphrases

dendritic cells
immune response
endothelial cells
regulatory t cells
cell cycle
peripheral blood
cell proliferation
risk assessment
human health