Analysis of Mutational Burden of Mitochondrial Genome in Cells of Different Human Organs and Tissues.

Margarita A Sazonova Vasily V Sinyov Anastasia I Ryzhkova Marina D Sazonova Natalya A Doroschuk Vasily P Karagodin Mikhail Aleksandrovich Popov Vasily Nikolaevich Sukhorukov Poggio Paolo Donato Moschetta Anton Yu Postnov

Published in: Current medicinal chemistry (2024)

The heteroplasmy level of mitochondrial genome mutations can significantly differ in the organs and tissues of individuals. In addition, in a number of literature sources, it is noted that there is a dependence on the mutational burden of the mitochondrial genome from the type of disease, sex, and age of a person.

Keyphrases

oxidative stress
induced apoptosis
gene expression
genome wide
endothelial cells
systematic review
risk factors
cell cycle arrest
drinking water
cell death
copy number