Association of decreased sperm motility and increased seminal plasma IGF-I, IGF-II, IGFBP-2, and PSA levels in infertile men.

Li FuKevin C J YuenAye Nyein TintAndrew R HoffmanAriff T BongsoKok Onn Lee

Published in: Endocrine (2021)

Decreased sperm motility, but not sperm count, in infertile AZ men is associated with increased SP IGF-I, IGF-II, IGFBP-2, and PSA levels. Changes in SP IGFs and their interactions with IGFBPs and IGF receptors, and PSA levels suggest a role of these SP peptides in modulating sperm motility and possibly prostate disease development in aging men.

Keyphrases

prostate cancer
pi k akt
binding protein
growth hormone
biofilm formation
middle aged
radical prostatectomy
signaling pathway
polycystic ovary syndrome
type diabetes
metabolic syndrome
peripheral blood
adipose tissue
cell proliferation
amino acid
benign prostatic hyperplasia